Jessica Yue (PhD, University of Toronto)
7-21A Medical Sciences Building
University of Alberta
Edmonton, Alberta Canada T6G 2H7
Tel: 780 248-5804
The brain plays an essential role in orchestrating the body’s homeostatic mechanisms. This is achieved by a continuous monitoring of nutritional and hormonal cues, which can collectively serve as an indicator of the body’s metabolic status and as a means of feedback. However, brain pathways that couple the body’s energy needs with nutrient intake and endogenous nutrient output are vulnerable to dysregulation in metabolic disorders such as obesity. As a result, excessive caloric intake further contributes to the obese state, and increased production of glucose and lipids by the liver leads to an increased risk for insulin resistance, diabetes, and cardiovascular disease. Obesity, diabetes, and cardiovascular disease are highly visible health concerns that affect growing numbers of Canadians as well as populations in developed and developing countries world-wide.
The research of the Yue laboratory focuses on delineating brain mechanisms which coordinate whole-body metabolism. More specifically, research is conducted to characterize stress-related hormone signalling pathways in the brain and the neurocircuitry that drive the regulation of hepatic fuel production, namely glucose and lipids, of feeding behaviour, and of body weight gain. The Yue laboratory encompasses methods in physiology, pharmacology, molecular biology, biochemistry, and genetics. In vivo experimental techniques include glucose clamp experiments with tracer dilution methodology to quantify whole-body glucose turnover, hepatic lipoprotein secretion experiments to study lipid metabolism, and energy monitoring systems to investigate feeding and locomotor behaviours in response to brain treatment interventions. The aim is to advance the current knowledge of the etiology and pathogenesis of obesity and diabetes. Consequently, prospective novel therapeutic signalling molecules in the brain could be identified to restore glucose, lipid, and energy homeostasis in individuals characterized by the metabolic syndrome.
Please see the link below for an example of our research:
JTY Yue, MA Abraham, MP LaPierre, PI Mighiu, PE Light, BM Filippi, TKT Lam. A fatty-acid dependent hypothalamic-DVC neurocircuitry that regulates hepatic secretion of triglyceride-rich lipoproteins. Nature Communications, 6: 5970, 2015.
- FA Duca & JTY Yue. Fatty acid sensing in the gut and hypothalamus: In vivo and in vitro perspectives. Molecular and Cellular Endocrinology, 397: 23-33, 2014.
- MP LaPierre, MA Abraham, BM Filippi, JTY Yue, TKT Lam. Glucagon and lipid signaling in the hypothalamus. Mammalian Genome, 25: 434-41, 2014.
- BM Filippi, A Bassiri, MA Abraham, FA Duca, JTY Yue, TKT Lam. Insulin signals through the dorsal vagal complex to regulate energy balance. Diabetes, 63: 892-899, 2014.
- MA Abraham, JTY Yue, MP LaPierre, GA Rutter, PE Light, BM Filippi, TKT Lam. Hypothalamic glucagon signals through the KATP channels to regulate glucose production. Molecular Metabolism, 3: 202-208, 2013.
- BM Filippi, MA Abraham, JTY Yue, TKT Lam. Insulin and glucagon signaling in the central nervous system. Reviews in Endocrine and Metabolic Disorders, 14: 365-375, 2013.
- JTY Yue, MC Riddell, E Burdett, DH Coy, S Efendic, M Vranic. Amelioration of hypoglycemia via somatostatin receptor type 2 antagonism in recurrently hypoglycemic diabetic rats. Diabetes, 62: 2215-2222, 2013.
- JTY Yue*, PI Mighiu*, BM Filippi, MA Abraham, M Chari, CKL Lam, NR Christian, CS Yang, MJ Charron, TKT Lam. Hypothalamic glucagon signaling inhibits glucose production. Nature Medicine, 19: 766-772, 2013.(* JTTY and PIM are co-first authors of this manuscript)
- JTY Yue, PI Mighiu, M Naples, K Adeli, TKT Lam. Glycine normalizes hepatic triglyceride-rich VLDL secretion by triggering the CNS in high-fat fed rats. Circulation Research, 110: 1345-1354, 2012.
- JTY Yue & TKT Lam. Lipid sensing and insulin resistance in the brain. Cell Metabolism, 15: 646-655, 2012.
- JTY Yue, E Burdett, DH Coy, A Giacca, S Efendic, M Vranic. Somatostatin receptor type 2 antagonism improves glucagon and corticosterone counterregulatory responses to hypoglycemia in streptozotocin-induced diabetic rats. Diabetes, 61: 197-207, 2012.
DM Breen, JTY Yue, BA Rasmussen, A Kokorovic, GWC Cheung, TKT Lam. Duodenal PKC-δ and cholecystokinin signaling axis regulates glucose production. Diabetes, 60: 3148-53, 2011.